huagongshe.com
HRID2052255

反应详情

EQUATION

反应方程式

HRID 2052255 的结构方程式

REACTANTS

反应物

3
结构：CS
HCID878

Methanethiol

CH4S

结构：[Na]
HCID5360545

Sodium

Na

结构：C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@@H]2OS(C)(=O)=O
HCID56609103

未命名化合物

PRODUCTS

生成物

1
结构：CS[C@@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID54358159

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

To 6.9 gm. of sodium metal dissolved in 225 ml. of ethanol is added 30 ml. of methylmercaptan followed by 10 gm. of 17β-methanesulfonyloxy-1,4-androstadiene-3,11-dione. Heat at reflux for 18 hours. Cool the solution to 0° C., filter solids and crystallize from chloroform/hexane to obtain the title compound; m.p. 180°-183° C.; [α]D26 +101.6° (DMF).

WORKUP

后处理

  1. temperatureHeat
  2. temperatureat reflux for 18 hours
  3. filtrationfilter solids
  4. customcrystallize from chloroform/hexane