HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichlorobenzenemethanethiol → 17alpha-(2',4'-Dichlorobenzylthio)-1,4-Androstadiene-3,11-Dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichlorobenzenemethanethiol | HCID 95756 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 17beta-Methanesulfonyloxy-1,4-androstadiene-3,11-dione | HCID 56609103 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 17alpha-(2',4'-Dichlorobenzylthio)-1,4-Androstadiene-3,11-Dione | HCID 22809847 | — |
Reaction Steps
To 1.04 gm. of sodium metal dissolved in 80 ml. of ethanol is added 5.55 ml. of 2,4-dichlorobenzylmercaptan followed by 1.5 gm. of 17β-methanesulfonyloxy-1,4-androstadiene-3,11-dione. Heat at reflux for 76 hours under an atmosphere of nitrogen. In a manner similar to that described in Example 1E, isolate the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04183924 |
| Source dataset | uspto-grants-1980_01 |
| ORD ID | ord-881461ffd3e64bccb82e2f4be6df9e76 |
| Source note | uspto-grants-1980_01 |