反应详情

温度

140 °C

A mixture of 75.0 g (0.7 mole) of 2,5-dimethylpyrazine and 41.0 g (0.5 mole) of dimethylamine hydrochloride was heated at 140° C. 60.0 g (38% aqueous solution) (0.75 mole) of formaldehyde was added over a period of two hours. After two hours additional heating the mixture was cooled. It was diluted with 110 ml of water, made basic with 10% sodium hydroxide and extracted with chloroform. The solvent was removed and the residue distilled to give 28.6 g of 2-(β-dimethylaminoethyl)-5-methylpyrazine, b.p. 106°-110° C. at 10 mm Hg.

1. temperatureAfter two hours additional heating the mixture
2. temperaturewas cooled
3. extractionextracted with chloroform
4. customThe solvent was removed
5. distillationthe residue distilled