Triethylamine → HCID 86736779, compound

HRID 2052292Notes

Reaction equation

HRID 2052292 reaction equation
C(N[CH2:4][CH2:5][C:6]1[CH:11]=[N:10][CH:9]=[CH:8][N:7]=1)C.C([N:14]([CH2:17][CH3:18])CC)C.Cl[C:20]([O:22][CH2:23][CH3:24])=[O:21]>C1C=CC=CC=1>[CH2:23]([O:22][C:20]([CH2:18][CH2:17][NH:14][N:7]1[CH:8]=[CH:9][N:10]=[CH:11][CH:6]1[CH2:5][CH3:4])=[O:21])[CH3:24]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10928Ethyl chloroformateHCID 11073599beta-Ethylaminoethylpyrazine

Product 1

HCID 86736779HCID 86736779, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 30.2 g (0.20 mole) of β-ethylaminoethylpyrazine in 240 ml of benzene and 56 ml (0.40 mole) of triethylamine was added dropwise over a period of 15 minutes 22.9 g (0.21 mole) of ethyl chloroformate. The mixture was refluxed for 1 hour. It was filtrated and the filtrate concentrated under vacuum. The residue was distilled to give 38.8 g of β-(N-ethoxycarbonylethylamino-ethylpyrazine, b.p. 100°-105° C. at 0.1 mm Hg.

Workup

  1. temperatureThe mixture was refluxed for 1 hour
  2. filtrationIt was filtrated
  3. concentrationthe filtrate concentrated under vacuum
  4. distillationThe residue was distilled

Sources & evidence

ORD record
ord-ea8133dc498b46a7955f99535d4efbee
Source dataset
uspto-grants-1980_01
Patent number
US04183933

Reaction notes

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