反应详情

To a solution of 30.2 g (0.20 mole) of β-ethylaminoethylpyrazine in 240 ml of benzene and 56 ml (0.40 mole) of triethylamine was added dropwise over a period of 15 minutes 22.9 g (0.21 mole) of ethyl chloroformate. The mixture was refluxed for 1 hour. It was filtrated and the filtrate concentrated under vacuum. The residue was distilled to give 38.8 g of β-(N-ethoxycarbonylethylamino-ethylpyrazine, b.p. 100°-105° C. at 0.1 mm Hg.

1. temperatureThe mixture was refluxed for 1 hour
2. filtrationIt was filtrated
3. concentrationthe filtrate concentrated under vacuum
4. distillationThe residue was distilled