反应详情

A solution of 3-[((1S)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-1-methylethyl)oxy]-N-(1-ethyl-1H-pyrazol-3-yl)-5-[(phenylmethyl)oxy]benzamide (2.40 g, 4.71 mmol) and THF (80 mL) was evacuated and purged with Argon (×3). Palladium on carbon (10%, 422 mg) was added and reaction mixture was evacuated and finally purged with hydrogen gas. Reaction mixture was left to stir at ambient temperature under hydrogen for 16 hours. Pd/C was filtered off and concentrated in vacuo to give the product as a colourless oil (1.87 g, 95%).

1. custompurged with Argon (×3)
2. additionPalladium on carbon (10%, 422 mg) was added
3. customreaction mixture
4. customwas evacuated
5. customfinally purged with hydrogen gas
6. customReaction mixture
7. waitwas left
8. filtrationPd/C was filtered off
9. concentrationconcentrated in vacuo