反应详情

To 300 ml of dry N,N-dimethylformamide was added 30. g (0.09 mol) of 2-bromo-1,2-di(4-methoxyphenyl)ethanone and 19.5 g (0.27 mol) of 2-amino-4,5-dihydro-3H-pyrrole. The mixture was stirred for three days at 25° with the exclusion of moisture. The reaction mixture was poured into water and the aqueous suspension was extracted three times with methylene chloride. The organic extracts were combined and washed six times with water, then dried (K2CO3). The solvent was evaporated and the residue was recrystallized from chloroform-hexane and dried overnight (80° in vacuo) to give the title compound, m.p. 146°-147.5°.

1. extractionthe aqueous suspension was extracted three times with methylene chloride
2. washwashed six times with water
3. dry with materialdried (K2CO3)
4. customThe solvent was evaporated
5. customthe residue was recrystallized from chloroform-hexane
6. customdried overnight (80° in vacuo)