反应详情

To 9.0 g (0.028 mol) of 2-chloro-1,2-di(4-methylthiophenyl)ethanone in 50 ml of dry N,N-dimethylformamide was added 7.0 g (0.084 mol) of 2-amino-4,5-dihydro-3H-pyrrole. The mixture was stirred for 48 hours at ambient temperature, then poured into 1 liter of ice containing 300 ml of 5% aqueous sodium carbonate solution. The precipitate was collected by filtration and dissolved in methylene chloride. The solution was washed with water, dried (K2CO3) and evaporated to give a residue which was chromatographed on alumina and eluted with methylene chloride-methanol (95:5) to give the title compound, m.p. 127°-128°.

1. filtrationThe precipitate was collected by filtration
2. dissolutiondissolved in methylene chloride
3. washThe solution was washed with water
4. dry with materialdried (K2CO3)
5. customevaporated
6. customto give a residue which
7. customwas chromatographed on alumina
8. washeluted with methylene chloride-methanol (95:5)