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HRID2052775

反应详情

EQUATION

反应方程式

HRID 2052775 的结构方程式

REACTANTS

反应物

2
结构：COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(C)=O)CC2
HCID6167

Colchicine

C22H25NO6

结构：C[S-].[Na+]
HCID4378561

Sodium thiomethoxide

CH3NaS

PRODUCTS

生成物

1
结构：COc1cc2c(c(OC)c1OC)-c1ccc(SC)c(=O)cc1[C@@H](NC(C)=O)CC2
HCID17648

Thiocholchicine

C22H25NO5S

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Colchicine (1.25 mmole) was dissolved in 10.0 mL of water to which was added sodium methanethiolate (7.13 mmol). The yellow solution was stirred for 24 hours, then extracted 3× with ETOH:Chloroform (1:1), then evaporated to yield the desired compound as yellow crystals.

WORKUP

后处理

  1. extractionextracted 3× with ETOH
  2. customChloroform (1:1), then evaporated