Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Chloroacetophenone | HCID 10757 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Product | HCID 86599625 | HCID 86599625 | 72% |
Reaction Steps
A mixture of piperazine (2 g, 23.22 mmol), 2-chloro-1-phenylethanone (7.89 g) and K2CO3 (8 g, 58.08 mmol) in 30 ml of DMF was stirred at 50° C. for 8 h, and treated according to the general preparation 2 to give 6.6 g of compound (IV-2) (72%), mp 258-259° C., M+ 322.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07326710B2 |
|---|
| Source dataset | uspto-grants-2008_02 |
|---|
| ORD ID | ord-90966a2af82b476c9a7e28ae2fc9e885 |
|---|
| Source note | uspto-grants-2008_02 |
|---|
