Piperazine → HCID 86599625, compound

HRID 2052807Notes

Reaction equation

HRID 2052807 reaction equation
N1C[CH2:5][NH:4][CH2:3]C1.[Cl:7][CH2:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].[C:17]([O-:20])([O-])=O.[K+].[K+].[CH3:23][N:24]([CH:26]=O)[CH3:25]>>[ClH:7].[ClH:7].[CH2:8]([N:4]1[CH2:3][CH2:26][N:24]([CH2:25][C:17]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:20])[CH2:23][CH2:5]1)[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10]

Participants

5

Reactant 4

HCID 4837PiperazineHCID 6228DimethylformamideHCID 107572-ChloroacetophenoneHCID 11430Potassium Carbonate

Product 1

HCID 86599625HCID 86599625, compoundYield 72%

Conditions

Temperature
50 °C

Procedure

A mixture of piperazine (2 g, 23.22 mmol), 2-chloro-1-phenylethanone (7.89 g) and K2CO3 (8 g, 58.08 mmol) in 30 ml of DMF was stirred at 50° C. for 8 h, and treated according to the general preparation 2 to give 6.6 g of compound (IV-2) (72%), mp 258-259° C., M+ 322.

Workup

  1. additiontreated
  2. customaccording to the general preparation 2

Sources & evidence

ORD record
ord-90966a2af82b476c9a7e28ae2fc9e885
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

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