HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroacetophenone → 1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroacetophenone | HCID 10757 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Piperazinecarboxaldehyde | HCID 82191 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2) | HCID 23080512 | — |
Reaction Steps
A mixture of N-formyl piperazine (20 g, 175 mmol), 2-chloro-1-phenylethanone (32.5 g, 210 mmol) and K2CO3 (36 g, 262 mmol) in 180 ml of acetone was treated according to the general preparation 1 to give N-phenacyl piperazine dihydrochloride, 28 g (57%), mp 246-8° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326710B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-c1ebb71f5a664fc7a5922ddadb654373 |
| Source note | uspto-grants-2008_02 |