反应详情

A mixture of N-formyl piperazine (20 g, 175 mmol), 2-chloro-1-phenylethanone (32.5 g, 210 mmol) and K2CO3 (36 g, 262 mmol) in 180 ml of acetone was treated according to the general preparation 1 to give N-phenacyl piperazine dihydrochloride, 28 g (57%), mp 246-8° C. (dec).

1. additionwas treated
2. customaccording to the general preparation 1