HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2052809Generated: October 30, 2026
Potassium Carbonate → N1-(2-naphthoylmethyl)-N4-phenacyl-piperazine dihydrochloride
https://huagongshe.com/reaction/2052809
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-2'-acetonaphthone | HCID 69179 | — |
| Reactant | 1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2) | HCID 23080512 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N1-(2-naphthoylmethyl)-N4-phenacyl-piperazine dihydrochloride | HCID 68810619 | — |
Reaction Steps
A mixture of 2-bromo-1-(naphthalen-2-yl)ethanone (0.95 g, 3.8 mmol), N-phenacyl piperazine dihydrochloride (0.89 g, 3.2 mmol) and K2CO3 (1.56 g, 11.2 mmol) in 30 ml of DMF was stirred at 50° C. for 10 h, and treated according to the general preparation 2 to give compound (IV-7), 0.88 g (60.69%), mp 236-237° C., M+ 373.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07326710B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-b4f8a03d753242808a4ebd9002bbed13 |
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| Source note | uspto-grants-2008_02 |
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