HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N1-(1-benzoylethyl)-N4-phenacyl-piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Bromo-1-phenylpropan-1-one | HCID 122432 | — |
| Reactant | 1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2) | HCID 23080512 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N1-(1-benzoylethyl)-N4-phenacyl-piperazine dihydrochloride | HCID 69223708 | — |
Reaction Steps
A mixture of 3-bromo-1-phenylpropan-1-one (1.5 g, 8.9 mmol), N-phenacyl piperazine dihydrochloride (2.05 g, 7.4 mmol) and K2CO3 (21.75 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-13), 0.64 g (76%), mp 204-205° C., M+ 336.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326710B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-259b4f9bacc74b8387070537b6316418 |
| Source note | uspto-grants-2008_02 |