Potassium Carbonate → N1-(1-benzoylethyl)-N4-phenacyl-piperazine dihydrochloride

HRID 2052813Notes

Reaction equation

HRID 2052813 reaction equation
Br[CH2:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[ClH:12].Cl.[CH2:14]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[C:15]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:16].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:12].[ClH:12].[C:4]([CH:3]([N:26]1[CH2:27][CH2:28][N:23]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])[CH2:24][CH2:25]1)[CH3:2])(=[O:5])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1224323-Bromo-1-phenylpropan-1-oneHCID 230805121-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

Product 1

HCID 69223708N1-(1-benzoylethyl)-N4-phenacyl-piperazine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 3-bromo-1-phenylpropan-1-one (1.5 g, 8.9 mmol), N-phenacyl piperazine dihydrochloride (2.05 g, 7.4 mmol) and K2CO3 (21.75 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-13), 0.64 g (76%), mp 204-205° C., M+ 336.

Workup

  1. additionwas treated
  2. customaccording to the general preparation 2
  3. customto give compound (IV-13), 0.64 g (76%), mp 204-205° C., M+ 336

Sources & evidence

ORD record
ord-259b4f9bacc74b8387070537b6316418
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

Loading…