HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2052815Generated: October 25, 2026
Potassium Carbonate → N1-phenacyl-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl]piperazine dihydrochloride
https://huagongshe.com/reaction/2052815
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one | HCID 13699429 | — |
| Reactant | 1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2) | HCID 23080512 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N1-phenacyl-N4-[1-(5-chloro-6-methoxy-2-naphthoyl)ethyl]piperazine dihydrochloride | HCID 69056005 | — |
Reaction Steps
A mixture of 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (3.8 mmol), N-phenacyl piperazine dihydrochloride (0.89 g, 3.2 mmol) and K2CO3 (1.56 g, 11.2 mmol) in 30 ml of DMF are stirred at 50° C. for 10 h, then was treated according to the general preparation 2 to give compound(IV-19), 1.09 g (61%), M+ 451.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07326710B2 |
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| Source dataset | uspto-grants-2008_02 |
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| ORD ID | ord-a42330afe57a44579729ba544260c208 |
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| Source note | uspto-grants-2008_02 |
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