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HRID2052815

反应详情

EQUATION

反应方程式

HRID 2052815 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COc1ccc2cc(C(=O)C(C)Br)ccc2c1Cl
HCID13699429

2-Bromo-1-(5-chloro-6-methoxy-2-naphthalenyl)-1-propanone

C14H12BrClO2

结构：Cl.Cl.O=C(CN1CCNCC1)c1ccccc1
HCID23080512

1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

C12H18Cl2N2O

PRODUCTS

生成物

1
结构：COc1ccc2cc(C(=O)C(C)N3CCN(CC(=O)c4ccccc4)CC3)ccc2c1Cl.Cl.Cl
HCID69056005

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
50 °C

PROCEDURE

实验过程

A mixture of 2-bromo-1-(5-chloro-6-methoxynaphthalen-2-yl)propan-1-one (3.8 mmol), N-phenacyl piperazine dihydrochloride (0.89 g, 3.2 mmol) and K2CO3 (1.56 g, 11.2 mmol) in 30 ml of DMF are stirred at 50° C. for 10 h, then was treated according to the general preparation 2 to give compound(IV-19), 1.09 g (61%), M+ 451.

WORKUP

后处理

  1. additionwas treated
  2. customaccording to the general preparation 2
  3. customto give compound(IV-19)