HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N1-phenacyl-N4-[2-(4-methoxybenzylamino)-2-oxo-ethyl]piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-chloro-N-(4-methoxybenzyl)acetamide | HCID 2404833 | — |
| Reactant | 1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2) | HCID 23080512 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N1-phenacyl-N4-[2-(4-methoxybenzylamino)-2-oxo-ethyl]piperazine dihydrochloride | HCID 86599627 | — |
Reaction Steps
A mixture of N-(4-methoxybenzyl)-2-chloroacetamide (3.65 mmol), N-phenacyl piperazine dihydrochloride (3.97 mmol) and K2CO3 (10.5 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-30)(61%), M+ 381.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326710B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-b539f06d7893415388648cfbfadd384d |
| Source note | uspto-grants-2008_02 |