Potassium Carbonate → N1-phenacyl-N4-[2-(4-methoxybenzylamino)-2-oxo-ethyl]piperazine dihydrochloride

HRID 2052818Notes

Reaction equation

HRID 2052818 reaction equation
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]([CH2:7][NH:8][C:9](=[O:12])[CH2:10][Cl:11])=[CH:5][CH:4]=1.[ClH:15].Cl.[CH2:17]([N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)[C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[ClH:11].[ClH:15].[CH2:17]([N:26]1[CH2:31][CH2:30][N:29]([CH2:10][C:9]([NH:8][CH2:7][C:6]2[CH:13]=[CH:14][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[O:12])[CH2:28][CH2:27]1)[C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:19]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 24048332-chloro-N-(4-methoxybenzyl)acetamideHCID 230805121-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

Product 1

HCID 86599627N1-phenacyl-N4-[2-(4-methoxybenzylamino)-2-oxo-ethyl]piperazine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of N-(4-methoxybenzyl)-2-chloroacetamide (3.65 mmol), N-phenacyl piperazine dihydrochloride (3.97 mmol) and K2CO3 (10.5 mmol) in 30 ml of DMF was treated according to the general preparation 2 to give compound (IV-30)(61%), M+ 381.

Workup

  1. additionwas treated
  2. customaccording to the general preparation 2
  3. customto give compound (IV-30)(61%), M+ 381

Sources & evidence

ORD record
ord-b539f06d7893415388648cfbfadd384d
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

Loading…