HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-phenacyl-N4-[2-(3,4-methylenedioxyphenylmethylamino)-2-oxo-ethyl] piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(1,3-benzodioxol-5-ylmethyl)-2-chloroacetamide | HCID 736835 | — |
| Reactant | 1-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2) | HCID 23080512 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 1-phenacyl-N4-[2-(3,4-methylenedioxyphenylmethylamino)-2-oxo-ethyl] piperazine dihydrochloride | HCID 86599628 | — |
Reaction Steps
A mixture of N-[1-(3,4-methylenedioxyphenyl)methyl]-2-chloroacetamide (5 mmol), N-phenacyl piperazine dihydrochloride (5 mmol) and K2CO3 (17.5 mmol) in 60 ml of acetone was treated according to the general preparation 2 to give compound (IV-32), 0.76 g (63.45%), M+ 395.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326710B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-27a48fba5e094f0787895c62d98b4e26 |
| Source note | uspto-grants-2008_02 |