Potassium Carbonate → 1-phenacyl-N4-[2-(3,4-methylenedioxyphenylmethylamino)-2-oxo-ethyl] piperazine dihydrochloride

HRID 2052820Notes

Reaction equation

HRID 2052820 reaction equation
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([CH2:10][NH:11][C:12](=[O:15])[CH2:13][Cl:14])=[CH:4][C:3]=2[O:2]1.[ClH:16].Cl.[CH2:18]([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)[C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[O:20].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[ClH:14].[ClH:16].[CH2:18]([N:27]1[CH2:32][CH2:31][N:30]([CH2:13][C:12]([NH:11][CH2:10][C:5]2[CH:6]=[CH:7][C:8]3[O:9][CH2:1][O:2][C:3]=3[CH:4]=2)=[O:15])[CH2:29][CH2:28]1)[C:19]([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:20]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 736835N-(1,3-benzodioxol-5-ylmethyl)-2-chloroacetamideHCID 230805121-Phenyl-2-(piperazin-1-yl)ethan-1-one--hydrogen chloride (1/2)

Product 1

HCID 865996281-phenacyl-N4-[2-(3,4-methylenedioxyphenylmethylamino)-2-oxo-ethyl] piperazine dihydrochloride

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of N-[1-(3,4-methylenedioxyphenyl)methyl]-2-chloroacetamide (5 mmol), N-phenacyl piperazine dihydrochloride (5 mmol) and K2CO3 (17.5 mmol) in 60 ml of acetone was treated according to the general preparation 2 to give compound (IV-32), 0.76 g (63.45%), M+ 395.

Workup

  1. additionwas treated
  2. customaccording to the general preparation 2
  3. customto give compound (IV-32), 0.76 g (63.45%), M+ 395

Sources & evidence

ORD record
ord-27a48fba5e094f0787895c62d98b4e26
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

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