HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroacetophenone → 2-(4-Benzyl-1-piperazinyl)-1-phenylethanone dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroacetophenone | HCID 10757 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Piperazine, 1-(phenylmethyl)-, hydrochloride (1:2) | HCID 12198046 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-(4-Benzyl-1-piperazinyl)-1-phenylethanone dihydrochloride | HCID 24213619 | 67% |
Reaction Steps
A mixture of N-benzyl-piperazine dihydrochloride (20 mmol, prepared by using the general preparation 3, yield 70%), 2-chloro-1-phenylethanone (24 mmol), K2CO3 (70 mmol) and KI(2 mmol) in 100 ml of acetone was treated according to the general preparation 2 to give N1-benzyl-N4-phenacyl piperazine dihydrochloride (67%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326710B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-690524b37b734d3f9c282f81f8701944 |
| Source note | uspto-grants-2008_02 |