2-Chloroacetophenone → 2-(4-Benzyl-1-piperazinyl)-1-phenylethanone dihydrochloride

HRID 2052821Notes

Reaction equation

HRID 2052821 reaction equation
[ClH:1].Cl.[CH2:3]([N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Cl:16][CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[ClH:16].[ClH:1].[CH2:3]([N:10]1[CH2:15][CH2:14][N:13]([CH2:17][C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:19])[CH2:12][CH2:11]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 107572-ChloroacetophenoneHCID 11430Potassium CarbonateHCID 12198046Piperazine, 1-(phenylmethyl)-, hydrochloride (1:2)

Product 1

HCID 242136192-(4-Benzyl-1-piperazinyl)-1-phenylethanone dihydrochlorideYield 67%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of N-benzyl-piperazine dihydrochloride (20 mmol, prepared by using the general preparation 3, yield 70%), 2-chloro-1-phenylethanone (24 mmol), K2CO3 (70 mmol) and KI(2 mmol) in 100 ml of acetone was treated according to the general preparation 2 to give N1-benzyl-N4-phenacyl piperazine dihydrochloride (67%).

Workup

  1. customprepared
  2. additionwas treated
  3. customaccording to the general preparation 2

Sources & evidence

ORD record
ord-690524b37b734d3f9c282f81f8701944
Source dataset
uspto-grants-2008_02
Patent number
US07326710B2

Reaction notes

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