Sulfuryl chloride → 4-amino-3-chloro-5-(trifluoromethyl)benzoic Acid

HRID 2052984Notes

Reaction equation

HRID 2052984 reaction equation
[NH2:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.S(Cl)([Cl:18])(=O)=O>C(Cl)(Cl)Cl>[NH2:1][C:2]1[C:10]([C:11]([F:12])([F:13])[F:14])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[Cl:18]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 32542864-Amino-3-(trifluoromethyl)benzoic acid

Product 1

HCID 46435494-amino-3-chloro-5-(trifluoromethyl)benzoic Acid

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

7.8 g (40 mmol) of 4-amino-5-trifluoromethylbenzoic acid in 80 ml of chloroform are placed in a 500 ml round-bottomed flask in the presence of 9.97 ml (50 mmol) of sulphuryl chloride, and the mixture is stirred under reflux overnight.

Workup

  1. temperatureunder reflux overnight

Sources & evidence

ORD record
ord-b5ef6b71af124755b154b59653141be3
Source dataset
uspto-grants-2008_02
Patent number
US07326722B2

Reaction notes

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