N-bromobutanimide → HCID 178501313, compound

HRID 2053014Notes

Reaction equation

HRID 2053014 reaction equation
[CH3:1][O:2][C:3]([C@H:5]1[CH2:8][C@H:7]([N:9]2[C:13]3[N:14]=[CH:15][N:16]=[C:17]([NH2:18])[C:12]=3[C:11]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH2:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)[CH:20]=3)=[CH:10]2)[CH2:6]1)=[O:4].[Br:33]N1C(=O)CCC1=O>CN(C)C=O>[CH3:1][O:2][C:3]([C@H:5]1[CH2:6][C@H:7]([N:9]2[C:13]3[N:14]=[CH:15][N:16]=[C:17]([NH2:18])[C:12]=3[C:11]([C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH2:26][C:27]4[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH:20]=3)=[C:10]2[Br:33])[CH2:8]1)=[O:4]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 178501315HCID 178501315, compound

Product 1

HCID 178501313HCID 178501313, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 11 g (25.67 mmol) trans-3-[4-amino-5-(3-benzyloxy-phenyl)-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclobutanecarboxylic acid methyl ester (see Example 4) in 275 ml dry N,N-dimethylformamide, 5.18 g (28.24 mmol) N-bromosuccinimide are added in small portions. The solution is stirred at RT in the dark and under Argon for 17 h. Thereafter the solvent is evaporated, and the residue purified by chromatography on silicagel (solvent: hexane-ethyl acetate 3:1). Further purification is done by crystallization from acetonitrile. Analytical HPLC: tR=3.61 min (shorty); ES-MS: m/eo=506.9 and 508.9; mp: 124-125° C.; NMR (DMSO-d6): 8.18/s (1H), 7.25-7.5/several m's (6H), 7.09/“d” (1H); 7.04/s (1H); 6.98/“d” (1H); 5.38/m (1H); 5.13/s (2H); 3.69/s (3H); 3.50/m (2H); 3.29/m (1H); 2.62/m (2H).

Workup

  1. customThereafter the solvent is evaporated
  2. customthe residue purified by chromatography on silicagel (solvent: hexane-ethyl acetate 3:1)
  3. customFurther purification
  4. customis done by crystallization from acetonitrile

Sources & evidence

ORD record
ord-052ded3e938541fb8469f7176c9131e3
Source dataset
uspto-grants-2008_02
Patent number
US07326699B2

Reaction notes

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