HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Diethylamino-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Chloro-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile | HCID 86612502 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Diethylamino-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile | HCID 68822232 | — |
Reaction Steps
4-Chloro-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile (10 mg) dimethylamine (18 ul) and triethylamine (50 ul) were stirred at room temperature in acetonitrile (500 ul) for one hour. After removal of solvent under reduced pressure, the residue was purified by preparative LCMS to give 4-diethylamino-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile (2.5 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326715B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-73b1691bb3184395a315462c6522bc21 |
| Source note | uspto-grants-2008_02 |