Triethylamine → 4-Diethylamino-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile

HRID 2053098Notes

Reaction equation

HRID 2053098 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:5]=[C:4]([C:18]#[N:19])[N:3]=1.[CH2:20]([N:22](CC)[CH2:23][CH3:24])[CH3:21]>C(#N)C>[CH2:20]([N:22]([CH2:23][CH3:24])[C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[N:5]=[C:4]([C:18]#[N:19])[N:3]=1)[CH3:21]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 866125024-Chloro-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile

Product 1

HCID 688222324-Diethylamino-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-Chloro-6-(3-trifluoromethylphenyl)-pyrimidine-2-carbonitrile (10 mg) dimethylamine (18 ul) and triethylamine (50 ul) were stirred at room temperature in acetonitrile (500 ul) for one hour. After removal of solvent under reduced pressure, the residue was purified by preparative LCMS to give 4-diethylamino-6-(3-trifluoromethyl-phenyl)-pyrimidine-2-carbonitrile (2.5 mg) as a white solid.

Workup

  1. customAfter removal of solvent under reduced pressure
  2. customthe residue was purified by preparative LCMS

Sources & evidence

ORD record
ord-73b1691bb3184395a315462c6522bc21
Source dataset
uspto-grants-2008_02
Patent number
US07326715B2

Reaction notes

Loading…