5-Bromo-2-chlorobenzoic acid → [3-(5-Bromo-2-chlorobenzoylamino)phenyl]acetic acid ethyl ester

HRID 2053142Notes

Reaction equation

HRID 2053142 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([Cl:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH2:23])[CH:18]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([NH:23][C:7](=[O:9])[C:6]2[CH:10]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=2[Cl:11])[CH:18]=1)[CH3:13]

Participants

3

Reactant 2

HCID 331275-Bromo-2-chlorobenzoic acidHCID 13042040Ethyl 2-(3-aminophenyl)acetate

Product 1

HCID 59654675[3-(5-Bromo-2-chlorobenzoylamino)phenyl]acetic acid ethyl ester

Procedure

5-Bromo-2-chlorobenzoic acid (132 mg, 0.56 mmol) was coupled with ethyl ester (6) (100 mg, 0.56 mmol) following Method C to give the title compound.

Sources & evidence

ORD record
ord-5c5dbf6bd0b84aa687724b56a02ff162
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

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