3,5-Dichlorophenylboronic acid → HCID 59654629, compound

HRID 2053246Notes

Reaction equation

HRID 2053246 reaction equation
C([O:3][C:4](=[O:22])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17](Br)[N:16]=2)=[O:14])[CH:7]=1)C.[Cl:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[C:28]([Cl:30])[CH:29]=1>>[Cl:23][C:24]1[CH:25]=[C:26]([C:17]2[N:16]=[C:15]([C:13]([NH:12][C:8]3[CH:7]=[C:6]([CH2:5][C:4]([OH:3])=[O:22])[CH:11]=[CH:10][CH:9]=3)=[O:14])[CH:20]=[CH:19][CH:18]=2)[CH:27]=[C:28]([Cl:30])[CH:29]=1

Participants

3

Reactant 2

HCID 27343313,5-Dichlorophenylboronic acidHCID 59654644HCID 59654644, compound

Product 1

HCID 59654629HCID 59654629, compound

Procedure

The pyridyl bromide (77)(44 mg, 0.12 mmol) was coupled to 3,5-dichloro-phenylboronic acid (20 mg, 0.10 mmol) using Method E. During this reaction, hydrolysis occurred. The residue was extracted using Work-up E1 to give the acid. The solid was further purified by preparative HPLC to give the title compound.

Workup

  1. customDuring this reaction, hydrolysis
  2. extractionThe residue was extracted
  3. customto give the acid
  4. customThe solid was further purified by preparative HPLC

Sources & evidence

ORD record
ord-690edc3264094bfd8fba9f4163a776f6
Source dataset
uspto-grants-2008_02
Patent number
US07326732B2

Reaction notes

Loading…