Ethyl 2-(3-aminophenoxy)acetate → (3-{[6-(3-Chloro-phenyl)-pyridine-2-carbonyl]-amino}-phenoxy)-acetic acid ethyl ester

HRID 2053254Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2053254
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH2:17]([O:19][C:20](=[O:30])[CH2:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH2:29])[CH:24]=1)[CH3:18]>>[CH2:17]([O:19][C:20](=[O:30])[CH2:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([NH:29][C:14]([C:12]2[CH:11]=[CH:10][CH:9]=[C:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)[N:13]=2)=[O:16])[CH:24]=1)[CH3:18]

Komponenten

3

Edukt 2

HCID 412308Ethyl 2-(3-aminophenoxy)acetateHCID 247301356-(3-Chlorophenyl)picolinic acid

Produkt 1

HCID 59654828(3-{[6-(3-Chloro-phenyl)-pyridine-2-carbonyl]-amino}-phenoxy)-acetic acid ethyl ester

Versuchsvorschrift

Carboxylic acid (136)(44 mg, 0.19 mmol) was coupled with aniline (64)(40 mg, 0.2 mmol) using Method D. The residue was purified by column chromatography eluting with 10% EtOAc in heptane to give the title compound.

Aufarbeitung

  1. customThe residue was purified by column chromatography
  2. washeluting with 10% EtOAc in heptane

Quellen und Nachweise

ORD-Eintrag
ord-7b75753f81b249a1928e0672a9b04263
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07326732B2

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