反应详情

Carboxylic acid (149)(50 mg, 0.21 mmol) was coupled to aniline (64)(42 mg, 0.21 mmol) using Method C. During this reaction, partial hydrolysis occurred. The residue was re-dissolved in EtOAc (2 ml) and the organic layer was washed with 1M HCl (2×1 ml), dried (Na2SO4), filtered and the solvent removed in vacuo to give a mixture of acid and ester, which was used without further purification.

1. customDuring this reaction, partial hydrolysis
2. washthe organic layer was washed with 1M HCl (2×1 ml)
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. customthe solvent removed in vacuo
6. customto give
7. customwas used without further purification