1,3-Benzodioxole-5-ethanamine → HCID 178518116, compound

HRID 2053306Notes

Reaction equation

HRID 2053306 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[O:20]1[C:24]2[CH:25]=[CH:26][C:27]([CH2:29][CH2:30][NH2:31])=[CH:28][C:23]=2[O:22][CH2:21]1.CCN(C(C)C)C(C)C>>[O:20]1[C:24]2[CH:25]=[CH:26][C:27]([CH2:29][CH2:30][NH:31][C:3]3[S:4]/[C:5](=[CH:9]\[C:10]4[CH:11]=[C:12]5[C:17](=[CH:18][CH:19]=4)[N:16]=[CH:15][CH:14]=[CH:13]5)/[C:6](=[O:8])[N:7]=3)=[CH:28][C:23]=2[O:22][CH2:21]1

Participants

4

Reactant 3

HCID 738741,3-Benzodioxole-5-ethanamineHCID 81531DiisopropylethylamineHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518116HCID 178518116, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, 2-benzo[1,3]dioxol-5-yl-ethylamine and DIEA to give (2-benzo[1,3]dioxol-5-yl-ethylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 404 (MH+).

Sources & evidence

ORD record
ord-41ec93ffa23a4dd78fb03bf951c5a9fe
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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