Histamine → HCID 178518130, compound

HRID 2053311Notes

Reaction equation

HRID 2053311 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[N:20]1[CH:24]=[C:23]([CH2:25][CH2:26][NH2:27])[NH:22][CH:21]=1.CCN(C(C)C)C(C)C>>[N:20]1[CH:24]=[C:23]([CH2:25][CH2:26][NH:27][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][CH:14]=[CH:13]4)/[C:6](=[O:8])[N:7]=2)[NH:22][CH:21]=1

Participants

4

Reactant 3

HCID 774HistamineHCID 81531DiisopropylethylamineHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518130HCID 178518130, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, 2-(3H-imidazol-4-yl)-ethylamine and DIEA to give 2-[2-(3H-imidazol-4-yl)-ethylamino]-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 350 (MH+).

Sources & evidence

ORD record
ord-eba8b8064796430c904cb5ad9dbb29e5
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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