Diisopropylethylamine → HCID 178518176, compound

HRID 2053314Notes

Reaction equation

HRID 2053314 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.Cl.[C:21]1([C@@H:27]2[CH2:29][C@H:28]2[NH2:30])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.CCN(C(C)C)C(C)C>>[C:21]1([C@@H:27]2[CH2:29][C@H:28]2[NH:30][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][CH:14]=[CH:13]4)/[C:6](=[O:8])[N:7]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 2723716Tranylcypromine hydrochlorideHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518176HCID 178518176, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, trans-2-phenyl-cyclopropylamine hydrochloride and DIEA to give 2-((1R,2S)-2-phenyl-cyclopropylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 372 (MH+).

Sources & evidence

ORD record
ord-7021bc610f464d03a7b5a364b0d4f964
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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