Diisopropylethylamine → HCID 178518191, compound

HRID 2053319Notes

Reaction equation

HRID 2053319 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[CH:20]1[CH:25]=[CH:24][C:23]([C@H:26]([NH2:29])[CH2:27][OH:28])=[CH:22][CH:21]=1.CCN(C(C)C)C(C)C>>[OH:28][CH2:27][C@@H:26]([NH:29][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1)[C:23]1[CH:24]=[CH:25][CH:20]=[CH:21][CH:22]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 1347972-Amino-2-phenylethan-1-olHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518191HCID 178518191, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, (S)-(+)-phenylglycinol and DIEA to give 2-((S)-2-hydroxy-1-phenyl-ethylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 376 (MH+).

Sources & evidence

ORD record
ord-56c97002dacb4cb5bb9ddb1d557e346b
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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