Diisopropylethylamine → HCID 178512081, compound

HRID 2053321Notes

Reaction equation

HRID 2053321 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.Cl.[S:21]1[CH:25]=[CH:24][CH:23]=[C:22]1[C:26](=[NH:28])[NH2:27].CCN(C(C)C)C(C)C>>[O:8]=[C:6]1[C:5](=[CH:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)[S:4][C:3]([NH:28][C:26]([C:22]2[S:21][CH:25]=[CH:24][CH:23]=2)=[NH:27])=[N:7]1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 2781759Thiophene-2-carboximidamide HydrochlorideHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178512081HCID 178512081, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, thiophene-2-carboximidamide hydrochloride and DIEA to give N-(4-oxo-5-quinolin-6-ylmethylene-4,5-dihydro-thiazol-2-yl)-thiophene-2-carboxamidine. LC-MS m/e 365 (MH+).

Sources & evidence

ORD record
ord-0cef6953eaee4d0584cd68650148f879
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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