Diisopropylethylamine → HCID 178518197, compound

HRID 2053324Notes

Reaction equation

HRID 2053324 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C@@H:28]([NH2:31])[CH2:29][OH:30])=[CH:23][CH:22]=1.CCN(C(C)C)C(C)C>>[F:20][C:21]1[CH:22]=[CH:23][C:24]([CH2:27][C@@H:28]([NH:31][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][CH:14]=[CH:13]4)/[C:6](=[O:8])[N:7]=2)[CH2:29][OH:30])=[CH:25][CH:26]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 28804567(2R)-2-Amino-3-(4-fluorophenyl)propan-1-olHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518197HCID 178518197, compound

Procedure

The similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, (R)-2-(4-fluoro-phenyl)-1-hydroxymethyl-ethylamine and DIEA to give 2-[(R)-2-(4-fluoro-phenyl)-1-hydroxymethyl-ethylamino]-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 408 (MH+).

Sources & evidence

ORD record
ord-dec0c77a1955434ca0bacb587e21137b
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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