Diisopropylethylamine → HCID 178456045, compound

HRID 2053330Notes

Reaction equation

HRID 2053330 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[OH:20][CH2:21][C@H:22]([NH2:25])[CH2:23][CH3:24].CCN(C(C)C)C(C)C>>[OH:20][CH2:21][C@H:22]([NH:25][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1)[CH2:23][CH3:24]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 27238562-Amino-1-butanol, (-)-HCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178456045HCID 178456045, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, (R)-1-hydroxymethyl-propylamine and DIEA to give 2-((R)-1-hydroxymethyl-propylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 328 (MH+).

Sources & evidence

ORD record
ord-cace12dfa9e544eba06593fc8e89f6d8
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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