Diisopropylethylamine → HCID 178518137, compound

HRID 2053335Notes

Reaction equation

HRID 2053335 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[NH2:20][CH:21]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[CH2:22][CH2:23][OH:24].CCN(C(C)C)C(C)C>>[OH:24][CH2:23][CH2:22][CH:21]([NH:20][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 2035001-Propanol, 3-amino-3-phenyl-HCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518137HCID 178518137, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, 3-amino-3-phenyl-propan-1-ol and DIEA to give 2-(3-hydroxy-1-phenyl-propylamino)-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 390 (MH+).

Sources & evidence

ORD record
ord-0156e50de33a4b8aae43dae2584e91c9
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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