Diisopropylethylamine → HCID 178514016, compound

HRID 2053336Notes

Reaction equation

HRID 2053336 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.Cl.[NH2:21][C@H:22]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:23]([NH2:25])=[O:24].CCN(C(C)C)C(C)C>>[O:8]=[C:6]1[N:7]=[C:3]([NH:21][C@H:22]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:23]([NH2:25])=[O:24])[S:4]/[C:5]/1=[CH:9]\[C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]=[CH:15][CH:14]=[CH:13]2

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 16216957(R)-2-Amino-2-phenylacetamide hydrochlorideHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178514016HCID 178514016, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, (R)-2-amino-2-phenyl-acetamide hydrochloride and DIEA to give (R)-2-{4-oxo-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-4,5-dihydro-thiazol-2-ylamino}-2-phenyl-acetamide. LC-MS m/e 389 (MH+).

Sources & evidence

ORD record
ord-432e21fc68ff4821827363a9818392d1
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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