Diisopropylethylamine → HCID 178518150, compound

HRID 2053339Notes

Reaction equation

HRID 2053339 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[F:20][C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=1[CH:28]([NH2:31])[CH2:29][OH:30].CCN(C(C)C)C(C)C>>[F:20][C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=1[CH:28]([NH:31][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1)[CH2:29][OH:30]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 148532692-Amino-2-(2,4-difluorophenyl)ethan-1-olHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518150HCID 178518150, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, 1-(2,4-difluoro-phenyl)-2-hydroxy-ethylamine and DIEA to give 2-[1-(2,4-difluoro-phenyl)-2-hydroxy-ethylamino]-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 455 (MH+).

Sources & evidence

ORD record
ord-6ba7ff0d29c6471f93d30ed4c3193d20
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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