Diisopropylethylamine → HCID 178518149, compound

HRID 2053340Notes

Reaction equation

HRID 2053340 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]([NH2:30])[CH2:28][OH:29])=[CH:23][CH:22]=1.CCN(C(C)C)C(C)C>>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([CH:27]([NH:30][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][CH:14]=[CH:13]4)/[C:6](=[O:8])[N:7]=2)[CH2:28][OH:29])=[CH:25][CH:26]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 148531952-Amino-2-(4-chlorophenyl)ethan-1-olHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178518149HCID 178518149, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, 1-(4-chloro-phenyl)-2-hydroxy-ethylamine and DIEA to give 2-[1-(4-chloro-phenyl)-2-hydroxy-ethylamino]-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 455 (MH+).

Sources & evidence

ORD record
ord-21e465ab6ece4dee9fac5babd5eb1a4f
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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