O-Methylhydroxylamine → HCID 178502628, compound

HRID 2053350Notes

Reaction equation

HRID 2053350 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[CH3:20][O:21][NH2:22].CCN(C(C)C)C(C)C>>[CH3:20][O:21][NH:22][C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1

Participants

4

Reactant 3

HCID 4113O-MethylhydroxylamineHCID 81531DiisopropylethylamineHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178502628HCID 178502628, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, methoxyamine and DIEA to give 2-methoxyamino-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 286 (MH+).

Sources & evidence

ORD record
ord-2c2c5d09011044b0913d5a4ae1fef560
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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