Diisopropylethylamine → HCID 178490617, compound

HRID 2053359Notes

Reaction equation

HRID 2053359 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C@@H:28]([NH2:30])[CH3:29])=[CH:24][CH:23]=1.CCN(C(C)C)C(C)C>>[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C@@H:28]([NH:30][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][CH:14]=[CH:13]4)/[C:6](=[O:8])[N:7]=2)[CH3:29])=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 793467(S)-1-(4-Methoxyphenyl)ethylamineHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178490617HCID 178490617, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, 1-(S)-(4-methoxy-phenyl)-ethylamine and DIEA to give 2-[(S)-1-(4-methoxy-phenyl)-ethylamino]-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 390 (MH+).

Sources & evidence

ORD record
ord-2ab7403a5ab34493aab237f280dd8bd7
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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