Diisopropylethylamine → HCID 178463617, compound

HRID 2053360Notes

Reaction equation

HRID 2053360 reaction equation
CS[C:3]1[S:4]/[C:5](=[CH:9]\[C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)/[C:6](=[O:8])[N:7]=1.[CH3:20][S:21]([C:24]1[CH:29]=[CH:28][C:27]([CH:30]([NH2:32])[CH3:31])=[CH:26][CH:25]=1)(=[O:23])=[O:22].CCN(C(C)C)C(C)C>>[CH3:20][S:21]([C:24]1[CH:29]=[CH:28][C:27]([CH:30]([NH:32][C:3]2[S:4]/[C:5](=[CH:9]\[C:10]3[CH:11]=[C:12]4[C:17](=[CH:18][CH:19]=3)[N:16]=[CH:15][CH:14]=[CH:13]4)/[C:6](=[O:8])[N:7]=2)[CH3:31])=[CH:26][CH:25]=1)(=[O:22])=[O:23]

Participants

4

Reactant 3

HCID 81531DiisopropylethylamineHCID 27369001-[4-(Methanesulfonyl)phenyl]ethan-1-amineHCID 58585737(5Z)-2-(methylthio)-5-(6-quinolinylmethylidene)-1,3-thiazol-4(5H)-one

Product 1

HCID 178463617HCID 178463617, compound

Procedure

Similar procedure as described in example 1b was used, starting from 2-methylsulfanyl-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one, 1-(4-methanesulfonyl-phenyl)-ethylamine and DIEA to give 2-[1-(4-methanesulfonyl-phenyl)-ethylamino]-5-[1-quinolin-6-yl-meth-(Z)-ylidene]-thiazol-4-one. LC-MS m/e 438 (MH+).

Sources & evidence

ORD record
ord-8b91532891f3404e9e66a5c6a2c6134e
Source dataset
uspto-grants-2008_02
Patent number
US07326786B2

Reaction notes

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