Morpholine → HCID 22495934, compound

HRID 2053372Notes

Reaction equation

HRID 2053372 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:21]([O-:23])=[O:22])=[C:6]([CH:20]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([S:16](F)(=[O:18])=[O:17])=[CH:12][CH:11]=1)=[O:8].[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[N:24]1([S:16]([C:13]2[CH:14]=[CH:15][C:10]([NH:9][C:7](=[O:8])[C:6]3[CH:20]=[C:2]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][CH2:25]4)[CH:3]=[CH:4][C:5]=3[N+:21]([O-:23])=[O:22])=[CH:11][CH:12]=2)(=[O:18])=[O:17])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 22495894HCID 22495894, compound

Product 1

HCID 22495934HCID 22495934, compound

Procedure

20.00 g (0.56 mol) of 4-(5-chloro-2-nitro-benzoylamino)-benzenesulfonyl fluoride in 48.5 g (0.557 mol) of morpholine were heated under reflux for 1 h. Subsequently the mixture was cooled, poured onto ice/hydrochloric acid and filtered with suction. 26.0 g (98%) of the title compound having a melting point of 252° C. were obtained.

Workup

  1. temperatureunder reflux for 1 h
  2. temperatureSubsequently the mixture was cooled
  3. additionpoured onto ice/hydrochloric acid
  4. filtrationfiltered with suction
  5. customwere obtained

Sources & evidence

ORD record
ord-1da467bb8f0341c7a7775be2608f315e
Source dataset
uspto-grants-2008_02
Patent number
US07326789B2

Reaction notes

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