反应详情

Employing the general trimethylaluminum coupling procedure and using (tert-butyl-dimethyl-silanyloxy)-phenyl-acetic acid methyl ester prepared in accordance with the procedures set out in Step 1 above and meso-1,2-diphenylethylene-diamine there is made: (4,5-Diphenyl-4,5-dihydro-1H-imidazol-2-yl)-phenyl-methanol trifluoroacetate. 1H NMR (DMSO) δ 10.95 (bs, 2H), 7.70-7.67 (m, 2H), 7.57-7.46 (m, 3H), 7.2-7.0 (m, 7H), 6.9-6.8 (m, 4H), 5.88 (s, 1H), 5.77 (s, 2H); LC/MS: 2.39 min/m/z 329 (M++1)

1. customprepared in accordance with the procedures