HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 178427018, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 3-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acid | HCID 12068686 | — |
| Reactant | HCID 178510549 | HCID 178510549 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 178427018 | HCID 178427018 | 99% |
Reaction Steps
Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine and C-(5-chloro-1H-benzimidazol-2-yl)methylamine in tetrahydrofuran. Yield: 99% (over 2 steps); Rf value: 0.77 (silica gel; dichloromethane/ethanol=4:1); C21H21ClN4O2 (396.88); mass spectrum: (M+H)+=397/399 (chlorine isotope).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07326791B2 |
| Source dataset | uspto-grants-2008_02 |
| ORD ID | ord-ba68ed6aab0f4ab0b6dfd5493fd5bfa9 |
| Source note | uspto-grants-2008_02 |