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HRID2053757

反应详情

EQUATION

反应方程式

HRID 2053757 的结构方程式

REACTANTS

反应物

5
结构：ClCl
HCID24526

Chlorine

Cl2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CN(C)C(On1nnc2ccccc21)=[N+](C)C.F[B-](F)(F)F
HCID2733207

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

C11H16BF4N5O

结构：Cc1cc(C(=O)O)ccc1C(=O)N1CCCC1
HCID12068686

未命名化合物

结构：NCc1nc2cc(Cl)ccc2[nH]1
HCID178510549

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C(=O)NCc2nc3cc(Cl)ccc3[nH]2)ccc1C(=O)N1CCCC1
HCID178427018

未命名化合物

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 1g from 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid, TBTU, diisopropylethylamine and C-(5-chloro-1H-benzimidazol-2-yl)methylamine in tetrahydrofuran. Yield: 99% (over 2 steps); Rf value: 0.77 (silica gel; dichloromethane/ethanol=4:1); C21H21ClN4O2 (396.88); mass spectrum: (M+H)+=397/399 (chlorine isotope).