Chlorine → HCID 178427135, compound

HRID 2053772Notes

Reaction equation

HRID 2053772 reaction equation
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[NH:6][C:7]([C@@H:9]([NH2:16])[CH2:10][C:11]3[N:12]=[CH:13][NH:14][CH:15]=3)=[N:8][C:4]=2[CH:3]=1.[CH3:19][C:20]1[CH:21]=[C:22]([CH:26]=[CH:27][C:28]=1[C:29]([N:31]1[CH2:35][CH2:34][CH2:33][CH2:32]1)=[O:30])[C:23](O)=[O:24].ClCl>ClCCl.CO>[Cl:1][C:2]1[CH:18]=[CH:17][C:5]2[NH:6][C:7]([C@@H:9]([NH:16][C:23](=[O:24])[C:22]3[CH:26]=[CH:27][C:28]([C:29]([N:31]4[CH2:32][CH2:33][CH2:34][CH2:35]4)=[O:30])=[C:20]([CH3:19])[CH:21]=3)[CH2:10][C:11]3[N:12]=[CH:13][NH:14][CH:15]=3)=[N:8][C:4]=2[CH:3]=1

Participants

5

Reactant 3

HCID 24526ChlorineHCID 120686863-Methyl 4-(pyrrolidin-1-ylcarbonyl)benzoic acidHCID 178511783HCID 178511783, compound

Product 1

HCID 178427135HCID 178427135, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 10d from (S)-1-(5-chloro-1H-benzimidazol-2-yl)-2-(1H-imidazol-4-yl)ethylamine and 3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzoic acid. Yield: 55% of theory. Rf value: 0.72 (silica gel; dichloromethane/methanol=4:1); C25H25ClN6O2 (476.97); mass spectrum: (M+H)+=477/479 (chlorine isotope).

Sources & evidence

ORD record
ord-b54d78bd49384fc9a9b3c8e3ab074b56
Source dataset
uspto-grants-2008_02
Patent number
US07326791B2

Reaction notes

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